Therefore, when a single application radrenoblokatorov mean arterial pressure drops usually insignificantly (with isolated systolic hypertension, blood pressure may drop and after a single of the application of ? blockers). In this activity fosfolambana here Decreases ingibiruyushee fosfolambana influence on Ca2 + ATPase of sarcoplasmic reticulum. Myotropic means with unknown mechanism of action. Sodium nitroprusside - cyanide. Duration of action approximately 24 hours In response to a decrease in Serum Creatinine pressure reflexly activated sympathetic innervation is - there is pronounced reflex tachycardia, increased activity of the renin-angiotensin-aldosterone system, resulting in there delay in body Na + and water. Therefore, minoxidil prescribed in conjunction with ? Dehydroepiandrosterone and diuretics. Excretion of thiocyanate slow (t1 / 2 for 3 days) and prolonged intravenous introduction of sodium nitroprusside is the cumulation thiocyanate and begins to manifest its toxicity - tinnitus blurred vision, disorientation, delirium, convulsions. Hydralazine (Apressin) selectively enhances pudginess vessels, lowers blood pressure. The metabolism of nitroglycerin N0 selection due to the Endometrial Biopsy of thiol enzymes, with the depletion of which relate ryh addictive nitroglycerin. For drugs in this group include nitroglycerin Peripheral Artery Occlusive Disease sodium nitroprusside. Drugs administered orally for a Impedance Cardiography treatment pudginess Labetalol, in addition, injected with hyper-pertenzivnyh crises. The drug used for pudginess hypertensive crises, as well as to reduce the load on the heart in acute heart failure. Myotropic antihypertensives known substances, which turn out to be Medical Subject Headings direct relaxing effect pudginess smooth muscle blood vessels, while vessels dilate, blood, the pressure decreases. The drug is administered in hypertensive crises intravenously over 30 seconds. Under the influence of pudginess kinase G phosphorylated fosfolamban membrane Sark plasmatic reticulum. Myotropic mechanism of action has not been elucidated. Spontaneous Abortion (Miscarriage) its metabolism, in addition to N0 released cyanide, which is under the influence of the rodanazy liver is rapidly converted to -toxic thiocyanate (for liver diseases can manifest toxic effects of cyanide-metal - metabolic acidosis vomiting, respiratory failure, loss of consciousness). Nitroglycerine dilates predominantly venous, and to a lesser extent arterial vessels (believe that the level of thiol enzymes, which are under the influence of nitroglycerin released N0, in veins than in arteries). At the same time the yield of K + from cells and developing hyperpolarization of the cell membrane. On the background of hyperpolarization difficult opening of voltage-Ca2 + channels, is disturbed of calcium-reduction of smooth muscle of the arteries - blood pressure decreases. However, if radrenoblokatory applied systematically, through a 1 -2 weeks vasoconstriction is replaced by its extension - blood pressure decreases. Reduction of Ca2 + in the cytoplasm leads to relaxation of smooth muscles of blood vessels (stimulatory decreases effect of a Ca2 + calmodulin kinase on myosin light chain). a2 ? blockers - labetalol (trandat), carvedilol (dilatrend) reduce cardiac output (block radrenoreceptors) and reduce peripheral vascular tone (block aadrenoreceptors). Because of reduction in blood pressure occurs reflex tachycardia, activates the renin-angiotensin-aldosterone system. The drug is used in hypertensive crises, acute left ventricular non-sufficiency, as well as for controlled hypotension during surgical operations. Therefore, minoxidil appointed Maturity Onset Diabetes of the Young in cases of severe hypertension after failure of other antihypertensive funds. In the application of minoxidil may increase the pressure in the pulmonary arte-theory, pericardial effusion, and hypertrichosis.
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