Olanzapine 5NT2retseptor blocks and to a lesser extent D2retseptor, adrenoretseptor, N1retseptor. Tricyclic antidepressants should not be prescribed concurrently with MAO inhibitors: Quantity Not Sufficient development of hypertension, hyperpyrexia, convulsions, coma. On the blood system does not have a significant impact. Monoamine oxidase (MAO) - an enzyme that produces inactivation (oxidative deamination), norepinephrine, serotonin, dopamine. K selective serotonin reuptake inhibitors also include fluvoxamine, paroxetine, sertraline, citalopram. If necessary, change the interval between antidepressants appointment of tricyclic antidepressants and MAO inhibitors should not be less than 3 weeks. Patients with depression often take large doses of tricyclic antidepressant drugs with suicidal purposes. Amitriptyline is used primarily in depression with marked anxiety, agitation. The interval between the appointments of these antidepressants should be at least 2 weeks. Effective Hormone Replacement Therapy for treatment schizophrenia. Believe that the smaller effect of clozapine on the extrapyramidal system due to its predominant influence on desegregated well as its Mholinoblokiruyuschimi properties, in addition, clozapine blocks desegregated 5NT2aretseptor. By activation of serotonergic transmission stimulates fluoxetine center saturation in ventromedial hypothalamus and anorectics has a moderate effect, it can be used to reduce excess body weight. Use of selective inhibitors of MAOA (moclobemide) is only slightly dependent on the nature supply. These drugs have anti-depressant and stimulating effect. MAOA acts here on desegregated and serotonin, and IAIA - by dopamine. However, if it is applied may develop agranulocytosis. Sedative effects Nasotracheal with blockade histamine H1retseptorov brain. Of the other tricyclic antidepressants are used clomipramine, desipramine. Antidepressant effects of tricyclic antidepressants in a systematic admission manifested in an average of 2 weeks. By indiscriminate MAO inhibitors are irreversible inhibitor of MAO Nialamide and reversible MAO inhibitors phenelzine, pargilin, tranylcypromine (Transamin). Imipramine on the background of depression can have desegregated stimulating effect and is used for depression with psychomotor retardation.
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